When you first set up VPOP3, and go into the VPOP3 settings, it will give you the option of running a setup wizard. For most users we recommend that you do this, as it will make sure you have the basic settings configured. However, if you want to set it up manually yourself, below are the things you need to do:

1. Set your Local Domain
2. Create a Connection and Mail Sender
3. Optionally create one or more Mail Collectors
4. Create your users and aliases
5. Enable virus scanning and/or spam filtering if you want to use it
6. Set your connection schedule and enable scheduling

You may also want to create distribution or mailing lists configuration